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KMID : 0389420110190040377
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Korean Journal of Stress Research
2011 Volume.19 No. 4 p.377 ~ p.382
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Association between FABP3 Polymorphism (rs10914367, -283A/G) and Obesity in Korean Population
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Youn Hyo-Chul
Yun Dong-Hwan
Kim Soo-Cheol
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Abstract
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Fatty acid binding proteins (FABPs) are a family of intracellular lipid-binding proteins. They play critical roles in intracellular fatty acid transport by binding lipids and regulating metabolic homeostasis. Heart FABP (H-FABP, also known as FABP3) is the most widely distributed FABP. To test the relationship between FABP3 polymorphism and dyslipidemia and obesity in Korean population, we analyzed 265 subjects. One single nucleotide polymorphism (SNP) (rs10914367, -283A/G) in the promoter region of the FABP3 gene was selected and was genotyped by direct sequencing. SNPStats and SNPAnalyzer Pro programs were performed to obtain odds ratio (OR), 95% confidence interval (CI), and p value. Multiple logistic regression models were conducted to analyze genetic data. The rs10914367 SNP was associated with obesity (p=0.017 in codominant2 model, p=0.028 in dominant model, p=0.014 in log-additive model, p=0.007 in allele frequencies). The A allele frequency of rs10914367 was higher in the overweigh/obese group (58.2%) than in the control group (46.0%), whereas the G allele frequency of rs10914367 was lower in the overweigh/obese group (41.8%) than in the control group (54.0%). The rs10914367 SNP was not related to the levels of total triglyceride and total cholesterol. These results suggest that a FABP3 polymorphism may be associated with obesity, and the A allele of rs10914367 may be a risk factor for the development of obesity in Korean population.
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KEYWORD
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Fatty acid-binding protein 3 (FABP3), Hyperlipidemia, Overweigh/obese, Single nucleotide polymorphism
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